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. Author manuscript; available in PMC: 2008 Oct 5.
Published in final edited form as: Cell. 2007 Oct 5;131(1):33–45. doi: 10.1016/j.cell.2007.08.017

Figure 5. CD4+CD25+ T-regulatory cells control TRUC.

Figure 5

(A) 4 week TRUC injected with PBS, 1×106 B cells, or 1×106 naïve T cells, WT or T-bet-/-. Colitis scores at 2 wks post-injection. Representative data from one of 3 exp, n=4 per group. (B). 4 week TRUC mice injected with 75,000 T-regs (CD4+CD25+CD62L+), WT or T-bet-/-, or PBS. Colitis scores at 4 wks post-injection. One representative exp of 3 is shown, n=6–8 per group. (C) Photomicrograph of TRUC colon (T-reg treated). T-regs (CD3, green) and DCs (CD11c, red), 400x. (D) Adoptive transfer of T-regs normalizes TRUC TNF-α levels. 4 week TRUC injected with 75,000 T-regs (CD4+CD25+CD62L+) or PBS. TNF-α levels from colon explant cultures 4 wks post-injection, RAG2-/- colon explants as a control. Samples pooled, n=4–5 per group.