FIG. 2.
Mononuclear cell infiltration of spleen, liver, and bone marrow of E/F; Mx1-cre mice. Results of histological examination of hematoxylin and eosin-stained sections from paraffin-embedded tissue are shown. The normal architecture of the spleen observed in pIpC-treated Mx1-cre or E/F (control) mice is disrupted by the presence of primitive mononuclear cells in pIpC-treated E/F; Mx1-cre mice. The white pulp (W), the lymphoid component of the spleen, is markedly reduced, while the red pulp (R) is greatly expanded by a myeloid/erythroid component, resulting in the homogeneous appearance of the spleen in pIpC-treated E/F; Mx1-cre mice compared to controls. The livers and bone marrow of pIpC-treated E/F; Mx1-cre mice were infiltrated by primitive mononuclear cells. Mice shown were analyzed at 17 days of age. Magnification, ×200 for spleen and liver sections and ×500 for bone marrow.