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. Author manuscript; available in PMC: 2008 Mar 30.
Published in final edited form as: Neuroscience. 2007 Feb 20;145(3):931–941. doi: 10.1016/j.neuroscience.2006.12.063

Fig.6.

Fig.6

Inhibition of εPKC activation reduced IPC-mediated neuroprotection and COX-2 expression in mixed cortical neuron/astrocyte cell cultures. (A) Histogram representing cell death, measured by LDH release at 48 h of reperfusion after OGD (4 h) injury. Note the loss of cell protection due to inhibition of εPKC activation using εPKC inhibitory peptide (εV1-2 at 20 nM) during IPC and 48 h of reperfusion. (B) Representative western blots of COX-2 and β-actin protein at 24 h of reperfusion after IPC. Data are the mean ± S.E.M. of normalized densitometry measurements from western blots of COX-2 compared with β-actin (n=5). ** p<0.01 compared with control, # p<0.05 compared with OGD, and & p<0.05 compared with IPC.