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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Virology. 2007 Apr 10;364(2):281–290. doi: 10.1016/j.virol.2007.02.022

Figure 3. The sensitivity of HIV-1 infection to CCR5 inhibitors in HeLa cell lines expressing different amounts of CCR5.

Figure 3

HeLa cell lines expressing high (JC.53) or low (JC.48) levels of CCR5 were infected with HIV-1 JR-FL pseudotype virus. The cells or virus were preincubated with CMPD167, U427,857, SCH-D, PRO 140, PRO 542 or Efavirenz at a range of concentrations. After 72 h, the cells were lysed, the luciferase acitivity was measured and the IC50 values for inhibition on the two cell lines were determined. The symbols each represent the ratio of IC50 values on the JC.53 cells over those on the JC.48 cells, calculated from five independent experiments.