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. 1999 Mar 22;144(6):1203–1218. doi: 10.1083/jcb.144.6.1203

Table III.

Synthetic Genetic Interactions Involving ARK1 and PRK1

Mutation(s) Temperature growth range* Actin organization Negative growth synergism
ark1Δ 15°C–37°C Normal —
prk1Δ 15°C–37°C Normal —
sac6Δ 15°C–34°C Depolarized patches, —
 fewer cables
sla1Δ 15°C–34°C Fewer, larger —
 patches, depolarized
sla2Δ 15°C–30°C‡ Larger number of —
 patches, depolarized
abp1Δ 15°C–37°C Normal —
srv2Δ 15°C–37°C§ Depolarized patches, —
 occasional actin bars
rvs167Δ 15°C–37°C Delocalized actin —
crn1Δ 15°C–37°C Normal —
aip1Δ 15°C–37°C Normal —
ark1Δ prk1Δ 20°C–34°C‡ Severly disrupted: Yes
 actin “clumps” and
 depolarized patches,
 fewer cables
ark1Δ sac6Δ 15°C‡–34°C‡ Larger number of Yes
 depolarized patches
prk1Δ sac6Δ 15°C–30°C‡ Larger number of Yes
 depolarized patches
ark1Δ sla1Δ 15°C–34°C Same as sla1Δ No
prk1Δ sla1Δ 15°C–34°C Same as sla1Δ No
ark1Δ sla2Δ 15°C–30°C‡ Same as sla2Δ No
prk1Δ sla2Δ Lethal‖ Yes
ark1Δ abp1Δ 15°C–37°C Normal No
prk1Δ abp1Δ 15°C–34°C‡ Severely disrupted: Yes
 actin “clumps” and
 depolarized patches
ark1Δ srv2Δ 15°C–37°C§ Same as srv2Δ No
prk1Δ srv2Δ 15°C–37°C§ Same as srv2Δ No
ark1Δ rvs167Δ 15°C–37°C Same as rvs167Δ No
prk1Δ rvs167Δ 15°C–37°C Same as rvs167Δ No
ark1Δ crn1Δ 15°C–37°C Normal No
prk1Δ crn1Δ 15°C–37°C Normal No
ark1Δ aip1Δ 15°C–37°C Normal No
prk1Δ aip1Δ 15°C–37°C Normal No
*

 Growth was tested at 15, 20, 25, 30, 34, and 37°C.  

‡

 Very slow growing at the indicated extremes of temperature.  

‖

 7 out of the 12 predicted double-mutant progeny were inviable.  

§

 Slow growing at the indicated extremes of temperature.