. 2007 Oct 12;8(2-3):107–119. doi: 10.1007/s10969-007-9027-2

Table 2.

Protein kinase structures determined by SGC

Name	PDB ID	Resolution [Å]	Inhibitor name	Disease link	Family
CLK1	1Z57	1.70	Hymenialdisine	Pot. Genetic^e	CMGC
CLK3^c	2EU9	1.53	none	Pot. Genetic^e	CMGC
CK1γ1	2CMW	1.75	Compound 52		CK1
CK1γ2	2C47	2.40	5-Iodotubercidin	Genetic	CK1
CK1γ3^d	2CHL	1.95	Triazolodiamine 1	Cancer	CK1
ERK3	2I6L	2.25	none	Cancer	CMGC
ASK1	2CLQ	2.30	Staurosporine	Inflammation, CV^f	STE
NEK2	2JAV	2.10	SU11652	Cancer	Other-NEK
PAK4^a	2CDZ	2.40	Cdk1 Inhibitor	Cancer	STE
PAK5	2F57	1.80	Cdk1 Inhibitor	Pot. Cancer	STE
PAK6	2C30	1.60	none	Cancer	STE
PIM1^b	1XWS	1.80	BIM I, HB1	Cancer, Inflammation	CAMK
PIM2	2IWI	2.80	HB1	Cancer, Inflammation	CAMK
SLK^c	2J51	2.10	Triazolodiamine 1	Pot. Cancer^e	STE
MPSK1	2BUJ	2.60	Staurosporine	Pot. Cancer^e	Other-NAK
STK10	2J7T	2.0	SU11274	Not known	STE
DAPK3	2J90	2.0	Pyridone 6	Cancer, Inflammation	CAMK
CAMK1G	2JAM	1.7	SU11652	Not known	CAMK
CAMK1D	2JC6	2.5	GSK inhibitor XIII	Genetic	CAMK

^aPAK4 also deposited as an apo-structure in two different spacegroups: 2BVA, 2J01

^bStructures with different inhibitors and substrate: PIM1: 2BIK, 2BZH,2BZI, 2BZJ, 2BZK, 2C3I, 2BIL, 2J2I; SLK: 2JA0

^cCLK3 also deposited as phosphorylated protein: pdb-code: 2EXE. Detailed description of structures of targets solved in Oxford is available in form of “iSee” datapacks freely downloadable on: http://www.sgc.ox.ac.uk/structures/KIN.html

^dCK1γ3 with different inhibitors: 2CHL, 2IZR, 2IZS, 2IZU, 2IZT

^eA formal link to the disease has not been established so far but is likely

^fCardiovascular disease