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Fig. 2. Glutamate inhibition of background potassium currents involved G proteins and PLC. (A) Recovery of TASK3 and TREK2 currents in the presence of 1 mM GTPγS in the patch–clamp pipette. (B and C) Glutamate inhibition of TASK3 and TREK2 currents before and after 15 min treatment with 5 µM PLC inhibitor U73122 (B) or its inactive analog U73343 (C). (D) Summary of the effects produced by U73122 (black bars) and U73343 (white bars). *P < 0.01.
