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. 1997 Sep 8;138(5):987–998. doi: 10.1083/jcb.138.5.987

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BzATP_o potently stimulates Ca²⁺ influx in thymocytes. (A) Of the nucleotides tested, BzATP_o proved to be the most effective nucleotide agonist stimulating a rise in thymocyte [Ca²⁺]_i. Individual thymocytes exhibit a nonuniform [Ca²⁺]_i response to 100 μM BzATP_o; 137 single-cell traces are displayed. (B) The single-cell [Ca²⁺]_i rise evoked by BzATP_o closely resembles the ATP_o-elicited response. A representative single-cell trace during BzATP_o application is shown. (Experiment 71595-7; Cell 30.) (C) The level of [Ca²⁺]_i at the peak and at the inflection point for 147 BzATP_o-sensitive thymocytes are plotted against time. Peak [Ca²⁺]_i levels show wide dispersion while threshold values are tightly clustered (experiments 71595-7 and 71595-23).