Table 2.
Included studies on effect of sibutramine on weight loss
| Study population | Mean age (years) | Mean BMI | Mean weight (kg) | Comparison | Attrition (% drug/placebo) | Cointerventions | ||
|---|---|---|---|---|---|---|---|---|
| Apfelbaumw17 | 205 underwent 4 week very low calorie diet, those who lost ≥6 kg (n=160) randomised to treatment or placebo, 1 year follow-up (France) | 38 | 35.5 | 104 | Sibutramine 10 mg daily (n=352); placebo (n=78) | 34/42 | Diet counselling | |
| Haunerw18 | 362 from primary care, 54 week follow-up (Germany) | 43 | 35.3 | 100 | Sibutramine 15 mg daily (n=180); placebo (n=182) | 40/48 | 2.1-4.2 MJ/day deficit diet; exercise; food diary | |
| Jamesw19 | 605 receiving sibutramine 5 mg daily and diet for 6 months, those who lost 5% of weight (n=467) randomised to treatment or placebo, 18 month follow-up (Europe) | 41 | 36.7 | 102 | Sibutramine 10-20 mg daily (n=352); placebo (n=115) | 15/28 | 2.5 MJ/day deficit diet; exercise counselling | |
| Kaukuaw20 | 236 with type 2 diabetes, 1 year follow-up (Finland) | 53 | 35.7 | 99 | Sibutramine 15 mg daily (n=114); placebo (n=122) | 11/11 | 2.9 MJ/day deficit diet | |
| Mathus-Vliegenw21 | 221 receiving very low calorie diet for 3 months. Those who lost ≥10% of weight (n=189) randomised to treatment or placebo, 18 months follow-up (Dutch) | 43 | 36.6 | 105 | Sibutramine 10-15 mg daily (n=94); placebo (n=95) | 35/39 | 2.5 MJ/day deficit diet | |
| McMahon 2000w22 | 224 with controlled hypertension, 1 year follow-up (36% African-American; US) | 53 | 34.3 | 97 | Sibutramine 20 mg daily (n=170); placebo (n=169) | 22/19 | Diet counselling | |
| McMahon 2002w23 | 220 with controlled hypertension. 1 year follow-up (US) | 51 | 33.9 | 98 | Sibutramine 20 mg daily (n=146); placebo (n=74) | 42/51 | Diet counselling | |
| McNultyw24 | 194 with type 2 diabetes, | 1 year follow-up (UK, Canada, France, Belgium) | 49 | 36.6 | 103 | Sibutramine 15 mg daily (n=68); placebo (n=62) | 28/21 | Diet counselling |
| Sanchez-Reyesw25 | 86 with type 2 diabetes treated with sulfonylureas, 1 year follow-up (Mexico) | 44 | 35.1 | 98 | Sibutramine 10 mg daily (n=44); placebo (n=42) | 45/45 | Diet and exercise counselling | |
| Smithw26 | 485 from primary care, 1 year follow-up (UK) | 42 | 32.7 | 87 | Sibutramine 10 mg daily (n=161); sibutramine 15 mg daily (n=161); placebo (n=161) | 42/49/51 | Diet counselling |