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. 2007 Sep 3;204(9):2015–2021. doi: 10.1084/jem.20070841

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — T-bet–dependent dysfunction of unhelped memory CD8⁺ T cells. (A and B) Wild-type or Tbx21 ^−/− mice were left untreated (No Tx) or treated with CD4-depleting antibody (0.2 mg GK1.5 i.p.; CD4 depleted) 1 d before and 1 d after LCMV infection. (A) Surface phenotype of GP33-specific CD8⁺ T cells from spleens 90 d after infection. Plots show H-2D^bGP33⁺ events; numbers represent the percentage of tetramer-positive cells expressing indicated surface marker. (B) Cytokine production of GP33-specific CD8⁺ T cells. Plots show CD8⁺ events; numbers indicate the percentage of cells producing both IFN-γ and IL-2 or CD40L in response to GP_33-41. Results are representative of two independent experiments.