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. 2007 May 14;204(5):1013–1024. doi: 10.1084/jem.20061523

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — IRAK-4 activity is critical for TLR-mediated proliferation of splenocytes. Splenocytes were cultured with the indicated concentrations of MALP-2, poly I:C, LPS, R-848, CpG-DNA, anti-IgM, or anti-CD40 for 48 h. Samples were pulsed with 1 μCi [³H]thymidine for the last 16 h. [³H]thymidine incorporation was measured by a scintillation counter. Data are representative of three independent experiments. Indicated values are mean ± SD of triplicates.