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. 2007 Apr 16;204(4):879–891. doi: 10.1084/jem.20061699

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — cbl-b^−/− effector CD8⁺ T cells are resistant to CD4⁺CD25⁺ T reg cell suppression. (A) Numbers of tumor infiltration for CD4⁺CD25⁺, FoxP3⁺, and CD8⁺ cells per 10⁶ tumor cells in cbl-b^−/− (n = 4 tumors) and cbl-b^+/+ (n = 6 tumors) mice. Data are shown as the mean ± the SEM. Proliferation of wild-type CD8⁺ effector T cells (B) and proliferation of cbl-b^−/− CD8⁺ effector T cells in the presence of cbl-b^+/+ and cbl-b^−/− CD4⁺CD25⁺ T reg cells at various T reg cell/Teff concentrations (C). Proliferation in B and C was measured by [³H]thymidine incorporation for the last 12 h of a 72-h stimulation with anti-CD3ɛ. Data (mean values of a triplicate culture ± the SEM) are from one out of three different experiments with similar results. (D) Percent suppression of proliferation of CD8⁺ effector T cells from cbl-b^−/− and cbl-b^+/+ mice by cbl-b^+/+ (WT) and cbl-b^−/− (KO) T reg cells at various T reg cell/Teff concentrations.