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. 2007 Nov 26;204(12):2977–2987. doi: 10.1084/jem.20070366

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Copyright © 2007, The Rockefeller University Press

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Figure 7. — p110γ regulates TCR-induced actin polymerization. (A and B) CD4⁺ (A) or CD8⁺ (B) purified T cells from p110γ^−/− and p110γ^+/− mice were stimulated with soluble anti-CD3 or anti-CD3 plus anti-CD28 mAb for the times indicated. Phalloidin staining was determined by flow cytometry and is expressed as the increase in mean fluorescence intensity over that observed at t = 0. Means ± SD are shown for three independent experiments. (C) p110γ interferes with actin polymerization in Jurkat T cells. Jurkat T cells were transfected with vector alone, p110γ, or p110γ-KR (48 h) and activated with soluble anti-CD3 or anti-CD3 plus anti-CD28 mAb for the times indicated. Phalloidin staining was determined by flow cytometry and is expressed as in A. Means ± SD are shown for three independent experiments.