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. 2007 Oct 29;204(11):2591–2602. doi: 10.1084/jem.20070634

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Copyright © 2007, The Rockefeller University Press

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Figure 7. — T. gondii–infected b2m⁻/⁻ mice display normal NK cell IFN-g production and succumb at the same time as CD8^−/− animals. WT, TAP-1^−/−, CD8^−/−, and β₂m^−/− mice (n = 5 per group) were infected i.p. with 20 ME-49 cysts. (A) PECs and spleens were harvested on day 3 after infection, and MHC class I expression was measure by FACS. The data shown are from animals within each group. The numbers indicate the percentage of positive cells (top) and mean fluorescence intensity (bottom). Filled histograms indicate background isotype control staining. (B and C) IFN-γ ICS of NK cells from 3-d infected mice ex vivo (B) or after restimulation with anti-NK1.1 mAb (C), as in Fig. 3. Values shown are the mean ± SD of assays on individual animals. (D) Survival of infected animals (n = 5 per group). The data shown in A–D are representative of three experiments performed. *, P < 0.05; ***, P < 0.001.