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. 2007 Oct 29;204(11):2667–2677. doi: 10.1084/jem.20062376

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — CD8 down-regulation is not induced by IFN-I alone. (A and B) Mice were adoptively transferred with WT OT-I cells and immunized with poly I:C with or without OVAp. At the indicated time point, spleens were harvested and CD8 expression and levels were analyzed. (A) The average CD8 expression levels (the mean ± the SD) on splenocytes from 3–4 mice per group are shown. Open symbols represent immunization with poly I:C alone, whereas closed symbols show responses induced by poly I:C plus OVAp. (B) Representative histograms from these same groups. (C) WT and IFN-IR^−/− OT-I cells were cotransferred and studied for CD8 expression levels 5 d after poly I:C plus OVA peptide immunization.