Figure 4.
Electrophysiological alterations in the αMHC-AT1 transgenic mice. ECG of αMHC-AT1 transgenic and nontransgenic littermate mice (offspring of line M4/7, captopril-treatment of the mothers) during the first 2 days after birth. Transgenic mice display severe bradycardia (A and B) with evidence of atrioventricular block (increased P–R interval) as well as a broadening of the QRS complex (A). Heart rate (B) was measured in 4 transgenic mice and 10 nontransgenic littermates, which were derived from a total of 3 litters. The mothers of these mice had received captopril through the drinking water from day 12 of pregnancy, as described.