Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Dec;18(12):5060–5068. doi: 10.1091/mbc.E07-04-0327

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2007 by The American Society for Cell Biology

PMC Copyright notice

Figure 2. — Mutation of individual SP/TP sites does not significantly alter tau toxicity in vivo. Compared with the organized structure of a normal eye (A), expression of tau^WT in the eye (under the control of the GMR-GAL4 driver) induces retinal degeneration and a rough eye phenotype (B). Tau^AP, in which all 14 SP/TP sites have been mutated to alanine has no significant toxicity when expressed at levels similar to tau^WT (C). By contrast, a rough eye phenotype indistinguishable from that induced by tau^WT is obtained upon retinal expression of each of the following tau mutants: tau^111/153 (D; T111A, T153A), tau^175/181 (E; T175A, T181A), tau^199/217 (F; S199A, T217A), tau^202/205 (G; S202A, T205A), tau²¹² (H; T212A), tau^231/235 (I; T231A, S235A), tau^396/404 (J; S396A, S404A), tau⁴²² (K; S422A), and tau²¹⁴ (L; S214A). Control is GMR-GAL4/+.