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Survival of CX3CR1–/– and CX3CR1+/+ recipient mice after cardiac transplantation. CX3CR1–/– mice rejected fully MHC-disparate cardiac allografts at the same tempo as CX3CR1+/+ recipients. However, whereas administration of a subtherapeutic dose of CsA prolonged allograft survival only 2–3 days in CX3CR1+/+ recipients, allograft survival was significantly prolonged in CX3CR1–/– mice treated with the same course of CsA (P < 0.005 Mann-Whitney vs. wild-type/CsA, n = 6/group).
