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Platelet shape change in Gαi2–/– mice. Shape change in response to ADP and thrombin was determined in WPs from wild-type (+/+) and Gαi2 knockout mice (–/–) as a decrease of light transmission in an aggregometer. Arrows indicate addition of agonists. Aggregation was prevented by addition of EDTA, and the amplitude of the tracings was amplified for clarity. The aggregometer tracings shown are representative of at least three independent experiments.
