Figure 2 (A) Activated areas during manic stimulation versus euthymic stimulation. During mania, an increase in regional cerebral blood flow (rCBF) was observed in the right superior frontal gyrus (Brodmann area (BA)10; p = 0.011), dorsolateral prefrontal cortex (DLPFC; BA9 and BA46; p = 0.011), inferior temporal gyrus (BA20; p<0.001); lateral premotor cortex (BA6; p = 0.011) and left anterior cingulate cortex (BA24; p = 0.017). (B) Activated areas during euthymic stimulation versus manic stimulation. During mania, a decrease in rCBF was observed in the left insula (p = 0.001), inferior parietal lobe (BA40; p = 0.008) and superior temporal gyrus (p = 0.03). The regions were overlaid on the single magnetic resonance image of the patient brain with statistical parametric mapping 99. The p values are corrected for multiple comparisons.