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. 2007 Aug 27;178(5):785–798. doi: 10.1083/jcb.200704108

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Copyright © 2007, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 9. — Sun1 topology and interactions. (A) Sun1 is envisaged as forming homodimers via interactions involving the membrane-proximal coiled coil within its C-terminal lumenal domain. Nucleoplasmic domain interactions may also contribute to homodimer formation. Sun1 functions as a tether for ONM nesprin proteins. Nesprins 1 and 2 provide links to the actin cytoskeleton, whereas nesprin 3 binds plectin, a versatile cytolinker. (B) Sun1 is associated with NPCs, and, in addition, its nucleoplasmic domain displays preferential binding to newly synthesized pre–lamin A. Therefore, Sun1 may provide a link between NPCs and the A-type lamins. In this way, the Sun1-mediated nucleation of A-type lamina assembly may occur at NPCs.