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Solution structure of human C5a determined from 1H NMR spectroscopy in H20/D2O (Zhang et al., 1997), showing (left) : four helices MLQK4KIEEIAAK12YKH (blue), SVV18KKCCYDGA26CVNN (orange), DE32TCEQRAA39RISLGP (black), R46CIKAFTQCCVVA63SQ (violet) joined by loops (green) and a C terminal D69GLGR74 (red), which adopts a 1.5 turn helix joined to the four helix bundle by a short loop (green); (right): electrostatic map showing residues with charged acidic (red) or basic (blue) side chains.
