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. Author manuscript; available in PMC: 2008 Nov 9.
Published in final edited form as: Biochem Biophys Res Commun. 2007 Sep 6;363(1):229–234. doi: 10.1016/j.bbrc.2007.08.166

Fig. 3.

Fig. 3

Model for the effects of solvent polarity and ligand concentration on the conformation and aggregation state of 2. At low concentrations, 2 is a monomer, with open and closed conformations populated depending on solvent polarity. In water, a polar solvent, the closed conformation predominates, whereas the open conformation predominates in less-polar solvents such as methanol. High ligand concentrations support aggregation. See text for details.