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. Author manuscript; available in PMC: 2008 Oct 4.
Published in final edited form as: Neuron. 2007 Oct 4;56(1):66–78. doi: 10.1016/j.neuron.2007.08.008

Figure 8. AICD Rescues ApoE and Cholesterol Defects in Cells Deficient in PS or APP.

Figure 8

(A-D) ApoE (A and B) and cholesterol levels (C and D) were measured in WT, PS-DKO and BACE1-KO MEF cells (A and C) and mouse brains (B and D). ApoE levels were decreased while cholesterol levels were increased in PS-DKO but not BACE1-KO MEF cells and mouse brain when compared to their WT controls. (E-H) APP/APLP2-DKO (E and G) and PS-DKO (F and H) MEF cells were transiently infected with retroviral vector control or AICD cDNA. LRP1 expression levels were then analyzed by Western blot, quantified by densitometry, and compared with those of WT MEF cells. Expression of AICD partially rescued apoE and cholesterol levels in both APP/APLP2-DKO and PSDKO MEF cells.