Fig. 5.
Inhibition of hippocampal glutamate transporter activity disrupts spatial memory retrieval in a NR2B receptor-dependent manner. (A) Summary of the time spent in the test (Qtest) and opposite quadrants (Qopp) for rats in the saline/PBS (n = 8), saline/dl-TBOA (n = 18), and Ro25-6981/dl-TBOA groups (n = 10). The saline and Ro25-6981 injections were given i.p., whereas the PBS and dl-TBOA injections were given intrahippocampally. *, Significant within-group difference between time spent in the Qtest and Qopp (P < 0.05); **, significant within-group difference between time spent in the Qtest and Qopp (P < 0.01); #, significant between-group difference in time spent in the Qtest for the saline/dl-TBOA and Ro25-6981/dl-TBOA groups (P < 0.05). (B) Representative locations of the infusion sites for the rats in the dl-TBOA experiments. Plates were adapted from Paxinos and Watson (47), and their distances posterior from bregma are indicated in millimeters.