Table 4.
Comparison with the prior literature
| Gene | Phenotype | Selected SNPs previously associated with phenotype | # SNPs in Affymetrix 100K within 60 kb of gene | # SNPs in Affymetrix 100K within 60 kb of Gene Locus and with r2 > 0.5 to previously reported SNP | SNP in Affymetrix 100K (r2 to previously reported SNP) | p for association in FHS 100K |
|---|---|---|---|---|---|---|
| APOE | LDL-C | rs429358 rs7412 |
1 | 0 | - | - |
| PCSK9 | LDL-C | rs11591147 | 7 | 0 | - | - |
| CETP | HDL-C | rs1800775 | 2 | 0 | - | - |
| LIPC | HDL-C | rs1800588 | 18 | 0 | - | - |
| LPL | HDL-C | rs328 | 8 | 2 | rs10503669 (r2 = 1.0) rs7007797 (r2 = 1.0) |
rs10503669 – 9.1*10-4 rs7007797 – 5.0*10-4 |
| LPL | TG | rs328 | 8 | 2 | rs10503669 (r2 = 1.0) rs7007797 (r2 = 1.0) |
rs10503669 – 0.02 rs7007797 – 0.002 |
| APOA5 | TG | rs662799 rs3135506 |
4 | 0 | - | - |