Figure 2.
(A) The hydropathy patterns of ChpC (solid line) and ChpG (broken line) illustrate the hydrophobic nature of the large (ChpA–C) and small (ChpD–H) chaplins. All chaplins have a signal sequence for secretion (SS). In ChpA–C, the two regions that conform to the sequences of the small chaplins (dark boxes) are followed by a hydrophilic region and a putative cell wall anchor containing an LAXTG motif and a stretch of hydrophobic amino acids. (B) Alignment of the homologous sequences present in the eight chaplins. The consensus sequence shows residues that are present in >50% of the sequences. The conserved amino acids, present in all sequences, are indicated in uppercase.