Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

Volume 80, no. 22, p. 11094-11104, 2006: Page 11095, Materials and Methods, Bulk viral sequencing and HCV genotyping, line 7: “5517M13F/6531M13R and 6430M13F/7481M13R” should read “3494M13F/4550M13R and 4441M13F/5627M13R.”

Page 11096: Add the following as the last paragraph of Materials and Methods.

Nucleotide sequence accession numbers. The HCV NS3 sequences from individuals studied in this article have been deposited in GenBank with the sequential accession numbers EF139657 through EF139773.

Due to the sequence length restrictions of GenBank, one HCV NS3 sequence could not be deposited into this database. This population-based study includes viral sequences with missing sequence relative to the HCV H77 reference sequence. The submitted sequences represent a median of 95% of the 1,893 nucleotides within NS3 (interquartile range of 59 to 100%). Missing sequence was not included in the analysis. We acknowledge that the availability of complete sequence for all individuals would have increased the power to detect significant associations at some residues. We wish to inform the readers that at the time of the submission of this Author's Correction, missing sequences and gaps are represented by the International Union of Pure and Applied Chemistry code “N” in GenBank, which can also denote undetermined bases. Note that sequence gaps are annotated as such for each sequence, but that the use of sequence formatting tools (e.g., FASTA) will not show annotated gaps. For this reason, the accompanying table includes a summary of the number of bases determined, the number and percentage of nucleotide mixtures, the number of undetermined bases (i.e., N's), the number of gaps, and the number of nucleotides, including gaps, for each accession number.