Figure 6.
A model for lateral distribution of yeast plasma membrane proteins. Left, confocal surface view a yeast cell expressing Sur7–GFP to reveal the MCC. Middle, schematic representation of a single MCC patch surrounded by MCP. Right, hypothetical representation of proteins distributed in the MCC and/or MCP. Proteins (white circles) are encased in a lipid shell (ring around white circle) of various composition and structure and that determines the segregation properties of proteins. Some proteins self-aggregate via their lipid shell to form MCC patches (proteins with white rings). These MCC proteins cannot aggregate with Pma1 nor (possibly) with other proteins (marked with black rings) that self-assemble to form the MCP. Other proteins such as Gap1 and Hxt1 (marked with gray rings) are surrounded by a lipid shell compatible with those encasing both MCC and MCP proteins, and thus they do not specifically segregate in MCC or MCP.