Figure 7.
Sequence comparison at the cDNA and protein level suggests that rTACC4 is a TACC3 variant initiating at an alternative 5′ start site. Schematic representation of BLAST 2 sequence (nucleotide) analysis of rabbit TACC4 (rTACC4; accession no. AF372837) and murine TACC3 (mTACC3; accession no. NM_011524) against human TACC3 (hTACC3; accession no. NM_006342). The length of the sequences, in base pairs, is bracketed under the sequence name. rTACC4 and mTACC3 were compared with hTACC3 sequence. The overall identities between rTACC4, or mTACC3, and hTACC3 are shown in large font while the identities of smaller segments are shown in small font. The lower levels of identity (≤60%) were insignificant from BLAST analysis and were obtained by PEPTOOL alignment of the sequences. (B) Schematic representation of BLAST 2 sequence (protein) analysis of rabbit TACC4 (rTACC4; accession no. AAK54244) and murine TACC3 (mTACC3; accession no. XP_132002) against human TACC3 (hTACC3; accession no. Q9Y6A5). The length of the sequences, in amino acids (aa), are bracketed under the sequence name. rTACC4 and mTACC3 were compared with hTACC3 sequence. The overall identities between rTACC4, or mTACC3, and hTACC3 are shown, whereas the level of identity between mTACC3 and rTACC4 is bracketed.