Skip to main content
. Author manuscript; available in PMC: 2008 May 18.
Published in final edited form as: Cell. 2007 May 18;129(4):723–733. doi: 10.1016/j.cell.2007.02.050

Figure 1. RA facilitates tumor growth in MMTV-neu mice.

Figure 1

Tumor growth was monitored in untreated female MMTV-neu mice and in mice subjected to systemic RA as of age 140 d. A. Sizes of tumors were measured with calipers with a start point (day 0) of tumor volume = 0.065 cm3. Volumes of tumors in untreated (closed symbols) and RA-treated (open symbols) on day 20 were 1.09 ± 0.22 cm3 vs. 1.87 ± 0.25 cm3 (mean ± SEM; n=12 in each group, P = 0.04). B. Mice were treated as described in a., and survival, defined as the age in which tumor volume reached 0.524 cm3, was assessed. Median survivals were 240 and 205 days for untreated mice (open symbols) and RA-treated mice (closed symbols, n=12 in each group, P = 0.001).