Table 2.
[11C]WAY 100635 BP values in the PET group and 5-HTTLPR and 5-HT1A receptor gene polymorphisms
|
|
Region |
SS (n = 10) |
SL (n = 17) |
LL (n = 8) |
SS plus SL (n = 27) |
LL (n = 8) |
|---|---|---|---|---|---|---|
| 5-HTTLPR | Raphe | 3.7 ± 1 | 3.8 ± 0.9 | 4.2 ± 0.8 | 3.8 ± 0.9 | 4.2 ± 0.8 |
| Postsynaptica | 4.1 ± 0.5 | 4.3 ± 0.5 | 4.7 ± 0.6 | 4.2 ± 0.5 | 4.7 ± 0.6 | |
|
|
|
GG (n = 6) |
CG (n = 18) |
CC (n = 11) |
GG plus CG (n = 24) |
CC (n = 11) |
| 5-HT1A [(−1018) C>G] | Raphe | 4.2 ± 0.7 | 3.8 ± 1 | 3.7 ± 0.9 | 3.9 ± 0.9 | 3.7 ± 0.9 |
|
|
Postsynaptica
|
4.4 ± 0.5 |
4.4 ± 0.6 |
4.1 ± 0.5 |
4.4 ± 0.5 |
4.1 ± 0.5 |
Values shown are mean ± SD.
5HTTLPR*:group allelic effect, F = 4.8, df = 1, 27, p = 0.037; scanner effect, F = 2.3, df = 1, 27, p = 0.1; gender effect, F = 1.4, df = 1, 27, p = 0.3; interaction effects, allele × scanner, F = 0.3, df = 1, 27, p = 0.6; allele × gender, F = 2.5, df = 1, 27, p = 0.1; scanner × gender, F = 0.6, df = 1, 27, p = 0.5; allele × scanner × gender, F = 0.4, df = 1, 27, p = 0.5.
5-HT1A (−1018 c>G)**: group allelic effect, F = 0.001, df = 1, 28, p = 0.973; scanner effect, F = 0.16, df = 1, 28, p = 0.9; gender effect, F = 2.1, df = 1, 28, p = 0.2; interaction effects, allele × scanner, F = 1.1, df = 1, 28, p = 0.3; allele × gender, F = 0.6, df = 1, 28, p = 0.4; scanner × gender, F = 1.7, df = 1, 28, p = 0.2.
*Repeated-measures ANOVA comparing the SS plus SL versus LL groups.
**Repeated-measures ANOVA comparing the CC versus CG plus GG groups.
Mean ± SD BP values of 20 corticolimbic regions of interest.