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Structure and potency of sEHIs used in this study
| Inhibitor | Structure | Human IC50 |
|---|---|---|
| AUDA-be |
|
0.8 nM |
| IK 950 |
|
4.3 nM |
Both inhibitors contain a urea primary pharmacophore. Although IK-950 is more water soluble compared to AUDA-be both inhibitors were effective topically when formulated into a cream. The IC50 refers to the potency of inhibition of the indicated compound on the recombinant human enzyme in vitro.
