Fig. 2.
Ab and memory CD8+ T cells protect from mousepox and death but only in immunocompetent mice. (A) Memory CD8+ T cells do not protect BALB/c mice unable to generate antibodies. Groups of four or five BALB/c or B cell KO mice were treated as indicated and challenged with ECTV in the footpad. Survival was monitored for 4 weeks. The experiment is representative of two. Data for B cell KO mice treated with memory CD8+ T cells correspond to a separate experiment where untreated B cell KO mice also died on day 6, and all BALB/c that received memory CD8+ T cells survived. (B) Antibodies do not protect mice unable to generate CD8+ T cell responses. Groups of five BALB/c mice were treated as indicated and infected with ECTV in the footpad. Survival was monitored for 4 weeks. The experiment shown is representative of three.