Table 1.
Renal Damage after Infusion of AngII
| Control | 3 Days | 7 Days | ||||
|---|---|---|---|---|---|---|
| AngII | Losartan + AngII | PD123319 + AngII | AngII | Losartan + AngII | ||
| Mesangial matrix expansion | − | − | − | − | +/++* | +/−† |
| Tubular injury score | − | + | − | + | ++/+++* | +/−† |
Quantification of mesangial matrix expansion and tubular injury. Results are expressed as semiquantitative score, as described in Materials and Methods. Four to eight animals were studied per group;
*P < 0.05 vs. control;
†P < 0.05 vs. AngII infusion.