Table 2.
Correlation between Intensity of Nuclear PTEN Staining and LOH Analysis
| Intensity of PTEN staining | Nucleus | Cytoplasm | ||
|---|---|---|---|---|
| LOH (%) | No LOH (%) | LOH (%) | No LOH (%) | |
| +++ | 0 (0) | 3 (100) | 0 (0) | 0 (0) |
| ++ | 9 (21) | 34 (79) | 8 (18) | 36 (82) |
| + | 12 (32) | 26 (68) | 15 (36) | 27 (64) |
| − | 6 (75) | 2 (25) | 4 (67) | 2 (33) |
Statistical correlation of PTEN intensity versus LOH performed using a Mantel-Haenszel test yielded results of χ21 = 8.70, P = 0.003 for nuclear and χ21 = 7.11, P = 0.008 for cytoplasmic PTEN staining, indicating a significant increase in LOH at 10q23 with decreasing PTEN stain intensity.