TABLE 1.
Different types of RTA responsiveness
| Promoter | Basal activitya | Activation (fold) by:
|
Known binding site(s) | ||
|---|---|---|---|---|---|
| C/EBPα | RTA | C/EBPα + RTA | |||
| RTA | 5 × 104 | 15 | 2 | 30 | C/EBP (n = 3) (OCT? [n = 1]) |
| C/EBPα | 2 × 104 | 20 | 3 | 55 | C/EBP (n = 1) |
| RAPd | 1 × 104 | 30 | 70 | 250 | C/EBPe (n = 2) |
| PANb | 5 × 104 | 30 | 110 | 500 | C/EBP (n = 2), RTA (n = 1) |
| MTAc | 3 × 103 | 140 | 440 | 1,700 | C/EBP (n = 2), CBF1 (n = 1) |
a
Relative luciferase activities of 200 ng of target plasmid DNA in HeLa cells.
b
Type II RRE.
c
Type IA RRE.
d
Type IB RRE.
e
Presumed additional unknown cellular DNA binding factor.