Table 2. .
Clinical Characteristics of Individuals Included in the Diabetes-Related Trait Analyses for the TCF7L2 rs7903146 Genotype[Note]
| Characteristics by Study |
|||||
| Characteristic | BCG | EFSOCH | 1958BC | NFBC1966 | ALSPAC |
| Na (% male) | 619 (52.8) | 1,810 (49.1) | 1,813 (49.7) | 4,486 (46.3) | 697 (53.8) |
| Median (IQRb) age, in years | 25.0 (24.5–25.6) | 31.0 (28.0–35.0) | 45.0 | 31.0 | 8.0 |
| Median (IQR) BMIc | 24.3 (22.0–27.3) | 24.8 (22.2–27.7)d | 26.5 (23.9–29.8) | 24.0 (19.2–28.8) | 16.2 (15.2–17.6) |
| Median (IQR) fasting plasma: | |||||
| Glucose, in mmol/liter | 4.6 (4.3–4.8) | 4.5 (4.2–4.8) | NA | 5.0 (4.5–5.5) | 4.9 (4.7–5.1) |
| Insulin, in pmol/liter | 39.6 (29.4–55.8) | 54.8 (40.4–79.0) | NA | 52.1 (29.2–75.0) | 33.3 (21.5–54.9) |
| HbA1c (IQR) [%] | NA | 5.1 (4.8–5.3) | 5.2 (5.0–5.5) | NA | 4.9e (4.7–5.1) |
Note.— NA=not available; IQR=interquartile range.
Includes white, unrelated individuals genotyped for rs7901346. When information was available, subjects with diabetes, HbA1c >6%, or fasting plasma glucose >6 mmol/liter were excluded.
IQR not applicable for 1958BC, NFBC1966, and ALSPAC, since participants were all studied at the same age.
Calculated as weight in kilograms divided by the square of height in meters.
Females were pregnant (28 wk gestation) at time of study, but BMI is the prepregnancy value.
HbA1c was measured in 1,280 subjects at age 7 years (50.6% male), whereas all other data in this column were gathered 1 year later. A total of 391 ALSPAC children were included at both times.