Table 1.
Characteristics of human members of SLC13 family and vertebrate orthologs. All are sodium dependent transporters found on plasma membranes. Only functionally characterized transporters are included
| Human gene | Protein names | Tissue distribution | Substrates | Orthologs | References |
|---|---|---|---|---|---|
| SLC13A1 | NaS1 (NaSi-1) | Kidney (human, rat), intestine (rat) | Sulfate, low affinity, Km sulfate 0.4 mM | Human, rat, mouse, eel | [5, 40, 46, 49] |
| SLC13A2 | NaDC1 (NaDC-1, NaC1) | Kidney (apical membrane), small intestine | Dicarboxylates, low affinity, Km succinate 0.8 mM | Human, rabbit, opossum, rat, mouse, Xenopus 1 | [2, 4, 13, 51, 52, 60, 64] |
| SLC13A3 | NaDC3 (SDCT2, NaC3) | Kidney (basolateral membrane), placenta, liver, brain | Dicarboxylates, high affinity, Km succinate 20 μM | Human, rat, mouse, Xenopus, flounder | [12, 37, 56, 65, 66] |
| SLC13A4 | NaS2 (SUT-1) | Placenta, endothelial venules, testis, heart, liver | Sulfate, low affinity, Km sulfate 0.4 mM | Human | [22, 48] |
| SLC13A5 | NaCT (NaC2) | Liver, brain, testis | Citrate (Km 0.6 mM), dicarboxylates | Human, rat, mouse | [31–33] |
1
The Xenopus laevis NaDC-2 has been renamed xNaDC1 because of sequence similarity to other NaDC1 orthologs.