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. 2007 May 2;104(19):8077–8082. doi: 10.1073/pnas.0702663104

Fig. 2.

Fig. 2.

Aortic root atherosclerosis was quantified on anti-Mac-3-stained cryosections by digital histomorphometry using ImagePro Plus software. Atherosclerosis in apoE−/−p110γ+/+ or apoE−/−p110γ+/− mice was compared with that in apoE−/−p110γ−/− mice. At 35 weeks (n = 8 for apoE−/−p110γ+/+ or apoE−/−p110γ+/− mice; n = 12 for apoE−/−p110γ−/− mice), double knockout mice displayed 52% reduction of lesion area (P = 0.0001). At 53 weeks (n = 8 for apoE−/−p110γ+/− mice; n = 7 for apoE−/−p110γ−/− mice), double knockout mice displayed 32% reduction of lesion area (P = 0.04). At 60 weeks (n = 7 for apoE−/−p110γ+/+ or apoE−/−p110γ+/− mice; n = 8 for apoE−/−p110γ−/− mice), double knockout mice displayed 36% reduction of lesion area (P = 0.0385). Error bars represent the SE of the mean.