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SRC-3−/− mice exhibit growth retardation and low levels of IGF-1. (A and B) Growth curves for females and males with different SRC-3 genotypes. Body weight is presented as average ± SE. (C) Serum IGF-1 measurement. All mice were males with an average age of 39.3 ± 6.4 days. (D) Correlation between IGF-1 concentrations and body weight for SRC-3−/− mice. Statistical t test indicates a very significant (P < 0.01) positive correlation (r = 0.828).
