Table 3.
Apolipoprotein Immunoreactivity in the Macula and Periphery of Normal and ARM Eyes
| Bruch’s membrane | Basal deposits | Drusen | ||
|---|---|---|---|---|
| Normal eyes (n) | ||||
| Apo B | Macula (12) | 4 | — | — |
| Periphery (12) | 9 | 12 | 90/101 (89%) | |
| Apo E | Macula (7) | 7 | — | — |
| Periphery (6) | 6 | 6 | 26/26 (100%) | |
| Apo C-III | Macula (7) | 0 | — | — |
| Periphery (6) | 0 | 1 | 0/22 (0%) | |
| ARM eyes (n) | ||||
| Apo B | Macula (5) | 4 | 2 | 16/29 (55%)* |
| Periphery (5) | 4 | 2 | 11/11 (100%)* | |
| Apo E | Macula (7) | 7 | 6 | 16/27 (60%)† |
| Periphery (5) | 5 | 5 | 15/17 (88%)† | |
| Apo C-III | Macula (7) | 0 | 0 | 0/13 (0%) |
| Periphery (5) | 0 | 1 | 0/10 (0%) |
Dash indicates lesions were absent. For Bruch’s membrane and basal deposits, numbers indicate eyes with the detectable protein. For drusen, numbers indicate ratio of drusen with protein to total drusen counted across eyes.
*Difference between macula and periphery significant (p = 0.0074).
†Difference between macula and periphery significant (p = 0.0496).