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. 2001 Dec;159(6):1987–1992. doi: 10.1016/S0002-9440(10)63049-0

Figure 3.

Figure 3.

Southern blot of genomic DNAs from t(15;19) cases 1 and 2, and normal lymphocytes (N). Novel restriction fragments are seen in the EcoRI, HindIII, and BamHI t(15;19) cell digests after hybridization to BRD4 (a) and Nop10p (b) probes. c: Exon-intron maps for long and short transcripts of BRD4. The t(15;19) translocation breakpoints interrupt the coding sequence of the long transcript (intron 10), and are approximately 4-kb 3′ to the end of the short transcript. d: Schematic of the BRD4 isoforms: BD, bromodomain; ET, ET domain; S, serine-rich region; P, proline-rich regions; Q, glutamine-rich region; *, kinase-like motifs. Vertical dotted lines define the translocation breakpoint region.