Figure 2.
Coronal sections (original magnification, ×50) stained with 6E10 against Aβ (brown), through the hippocampus and cortex in a Tg control (A) and K6Aβ1-30-treated (B) Tg mouse. C and D are adjacent sections (original magnifications, ×100) double-stained for interleukin-1β (black) that recognizes microglia, and Aβ (red). Note the reduction of amyloid burden in the immunized mouse (B), and the lack of ramified microglia (D) surrounding Aβ plaque in the same mouse, compared to a control mouse (A and C). Scale bars, 100 μm (A and C). Abbreviations: hip, hippocampus; cx, cortex; ml, corpus callosum.