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Overall survival of 115 patients with thyroid carcinoma dichotomized according to membrane β-catenin immunoreactivity (a). Eighty-five of the 115 cases had membrane β-catenin H scores >20. Survival in the same cohort according to aberrant Wnt activation (β-catenin nuclear immunoreactivity and/or CTNNB1 exon 3 mutation detected by SSCP) (b). β-catenin nuclear immunoreactivity and/or CTNNB1 exon 3 mutation by SSCP were detected in 32 of the 115 cases.
