Figure 3.
Intraneuronal fibrillary tau lesions contain tau immunoreactive straight filaments. Pre-embedding immuno-EM shows tau immunoreactive straight filaments using the 17026 (A, C, and E) and PHF1 (B, D, and F) antibodies. The tau immunoreactive filaments labeled with 17206 anti-tau antibody in A are shown at higher magnification (see arrows in C) (bottom box) and E (top box) from areas marked by the squares in A. Arrows and arrowheads in B point to PHF1-labeled filaments around the nucleus and in neurite, respectively. Irregularly arranged PHF1-labeled straight filaments in neuronal perikarya and processes (see arrows in F) from the area in the square in D. Scale bars, 2 μm (A, B, and D) and 500 nm (C, E, and F).