Figure 4.
Thioflavine-S staining of the arterial circle of Willis from a 24-month-old APP/Ld mouse. A: The main branches of the arteries at the base of the brain are almost completely free of amyloid, whereas the smaller branches show prominent amyloid deposition. B: High magnification of a branch of the middle cerebral artery showing focal amyloid deposits. C: Branch of middle cerebral artery with a pattern of fluorescence in concentric rings. D: No amyloid deposition in the internal carotid artery. ICA, internal carotid artery; MCA, middle cerebral artery; ACA, anterior cerebral artery; and PCA, posterior communicating artery. Scale bars, 200 μm (A), 80 μm (B), 100 μm (C), and 90 μm (D).