Figure 6.

Concomitant β-catenin and EGFR increase in pediatric hepatoblastomas. (A) Low-power view (original magnification, 5×) shows β-catenin distribution in a pediatric liver with hepatoblastoma. (B) An adjacent section displays a similar distribution of EGFR in the same tumor (original magnification, 5×). (C) Another hepatoblastoma displays aberrant nuclear β-catenin localization in the tumor (original magnification, 20×). (D) An adjacent section shows abnormal EGFR up-regulation in the same sample (original magnification, 20×). (E) Another patient also displays abnormal β-catenin localization in the hepatoblastoma (original magnification, 20×). (F) A consecutive section displays a similar anomalous increase in EGFR (original magnification, 20×). (G) Another hepatoblastoma sample shows abnormal cytoplasmic and nuclear 3-catenin (original magnification, 20×). (H) No EGFR was observed in the adjacent section in this tumor (original magnification, 20×).