Table 4.

Results of joint random effects modeling of MEM and EXEC baseline and change in association with MRI baseline and change from baseline measures

Dependent variable	Independent variable	Regression coefficient	Standard error	p
Memory baseline	CGM baseline	2.10	2.45	0.39
	HC baseline	7.48	1.46	0.0001
	LAC baseline	−0.35	1.03	0.73
Memory change	CGM baseline	0.18	0.32	0.56
	HC baseline	0.69	0.25	0.008
	LAC baseline	0.11	0.18	0.54
	CGM change	−1.62	1.10	0.14
	HC change	5.72	1.82	0.002
	LAC change	−2.08	1.44	0.14
Executive baseline	CGM baseline	2.20	2.00	0.27
	HC baseline	4.38	1.19	0.0003
	LAC baseline	−2.66	0.83	0.002
Executive change	CGM baseline	0.55	0.25	0.03
	HC baseline	0.03	0.20	0.90
	LAC baseline	−0.24	0.14	0.09
	CGM change	1.71	0.83	0.04
	HC change	4.01	1.37	0.004
	LAC change	−2.97	1.08	0.006

Regression coefficients, standard errors, and p values are from simultaneous modeling of memory (MEM) and executive function (EXEC) using baseline and change in cortical gray matter volume (CGM), hippocampal volume (HC), and lacune volume (LAC) as jointly entered independent variables. Standardized MRI variables were used for this analysis. Regression coefficients indicate differences in memory and executive function measures associated with a 1.0 SD difference in the respective MRI variable.