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. 2006 Dec 11;51(3):1085–1088. doi: 10.1128/AAC.00954-06

TABLE 2.

Synergistic activity of pairs of antimicrobial agents against Burkholderia cepacia complex isolated from patients with cystic fibrosis, 1996 to 2004

Antimicrobial pair No. of strains tested Ranges tested (μg/ml) Strains tested (%)
Synergistic Nonsynergistic Antagonistic Indeterminate
Aztreonam + tobramycina 216 4-32/1-8 6 10 2 82
Cefepime + chloramphenicolb 1,903 2-16/2-16 4 24 0 72
Ceftazidime + chloramphenicolc 2,405 2-16/2-16 10 48 1 41
Ceftazidime + trimethoprim-sulfamethoxazolec 2,405 2-16/0.25-2 6 38 2 54
Ceftazidime + amikacina 216 4-128/4-32 15 45 7 33
Ceftazidime + tobramycina 216 4-128/1-8 12 46 9 33
Chloramphenicol + ciprofloxacinb 1,903 2-16/0.25-2 1 17 0 82
Chloramphenicol + trimethoprim-sulfamethoxazoled 502 4-32/1-32 1 44 1 54
Ciprofloxacin + trimethoprim-sulfamethoxazoled 502 0.5-16/1-8 1 27 1 71
Doxycycline + chloramphenicolb 1,903 2-16/1-8 7 45 0 48
Doxycycline + trimethoprim-sulfamethoxazoleb 1,903 1-8/0.5-4 1 43 0 56
Imipenem + ciprofloxacine 718 0.5-16/0.5-4 5 29 1 65
Imipenem + tobramycina 216 0.5-16/1-8 4 17 3 76
Imipenem + amikacina 216 0.5-16/4-32 3 16 3 78
Meropenem + chloramphenicolb 1,903 1-8/2-16 4 54 2 40
Meropenem + ciprofloxacinc 2,405 1-8/0.5-2 4 57 2 37
Meropenem + doxycyclineb 1,903 1-8/1-8 7 64 2 27
Meropenem + tobramycinb 1,903 1-8/1-8 3 51 2 44
Meropenem + trimethoprim-sulfamethoxazoleb 1,903 1-8/0.25-2 4 44 2 50
Minocycline + chloramphenicold 502 1-32/4-32 9 88 1 2
Piperacillin + ciprofloxacinf 2,621 8-64/0.25-2 10 27 1 62
Piperacillin + tobramycina 216 8-64/1-8 9 19 0 72
Ticarcillin-clavulanate + tobramycina 216 8-64/1-8 5 8 0 87
a

Used from January 1996 to August 1997.

b

Used from October 1999 to December 2004.

c

Used from August 1997 to December 2004.

d

Used from August 1997 to October 1999.

e

Used from January 1996 to October 1999.

f

Used from January 1996 to December 2004.